The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.
Alienated teen Pauline struggles with the pressures of fitting into high school, pleasing her mother and a burning desire to lose her virginity. With a grotesque curiosity for the darker side of life, Pauline is considered a social outcast by everyone around her. Enticed by flesh, she retreats into her own fantasies and hopes to become a great surgeon - that is, if she doesn't go insane first.
A crew from a paranormal reality television show lock themselves in a haunted psychiatric hospital. They search for evidence of paranormal activity as they shoot what ends up becoming their final episode.
A socially awkward veterinary assistant with a lazy eye and obsession with perfection descends into depravity after developing a crush on a boy with perfect hands.