The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.
Suspecting that people are transforming into malevolent shape-shifters, Wyatt flees to New York City to seek out his estranged childhood friend Christian.
Ash Williams and his girlfriend Linda find a log cabin in the woods with a voice recording from an archaeologist who had recorded himself reciting ancient chants from "The Book of the Dead." As they play the recording an evil power is unleashed taking over Linda's body.
A socially awkward veterinary assistant with a lazy eye and obsession with perfection descends into depravity after developing a crush on a boy with perfect hands.
Alienated teen Pauline struggles with the pressures of fitting into high school, pleasing her mother and a burning desire to lose her virginity. With a grotesque curiosity for the darker side of life, Pauline is considered a social outcast by everyone around her. Enticed by flesh, she retreats into her own fantasies and hopes to become a great surgeon - that is, if she doesn't go insane first.
A man imprisons his estranged junkie friend in an isolated cabin in the boonies of San Diego to force him through a week of sobriety, but the events of that week are being mysteriously manipulated.